by Cynthia Green from NJIE November 5
Professor J Dumanov,
is a medical mycologist, clinical research pathologist in diagnostic medical
mycology specializing in the study of allergenic, toxigenic, pathogenic and
infectious fungi, molds and their pleomorphs within human habitations relevant
to human and animal health. The nationally and internationally
recognized scientist conducts indoor health risks research and investigative studies
for federal, state and local government and the private sectors.
Also as a clinical research lecturer and counsellor at law (non-attorney) he has trained, certified and
provided consultation to thousands of professionals including
medical doctors, clinical researchers, attorneys, academics, real estate, commercial,
industrial and related fields where mold poses health or legal
He sometimes refers to himself as
the "House Doctor"
where his patients are sick houses, buildings and other habitations.
Working with medical doctors and their patients he is routinely
called by those suffering from allergies or asthma, sick or
infected medical patients. He conducts subClinical
(tm) investigations and makes a "diagnosis"of
the patients environment. If there is a concern or problem
he prescribes a "treatment"
for the habitation as need. He appears
in the coming December 15
at 8 and 11 PM
Health Channel show entitled
Your House Out to Get You?" Rebroadcast
December 17 at 1 PM. (If you are reading this at a later date
check your local cable listing for a repeat showing or obtain
when available from the Discovery Health Channel).
Scientists, doctors and researchers in the show uncover many of the potential
risks hidden in the home including possibilities for burns,
shocks and explosions from appliances and more. With mold
getting so much attention from an infection in Ed McMahon's
dog to Bianca Jagger's loss of habitability of her New York
City apartment the interest in mold is at an all time high.
Our mycologist discusses
some of his cases and talks about the risks and hazards associated
with mold within the home or workplace. This includes the
possibility of getting sick from contacting mold spores
and fragments, touching mold covered items and damage to the
Important topics are covered especially
for the first time home owner. Get the family together and
get ready to watch "Is
Your House Out to Get You?" on Thursday, December 15 8 PM and other dates/times - see your local cable or satellite
In what turned out to be not only
an exclusive 2 hour recorded interview (edits
with permission. Ed.) with the professor,
also turned out to be quite startling with his revelations of discoveries
in his unpublished research. We conducted this interview shortly
after the final taping of this show in midtown Manhattan we
asked Doctor (hon) Dumanov (founder
- Mycological Institute FMHH ) what do we know
about mold in the home and what is science telling us:
Are there true risks associated with
mold in the home? "Simply,
a fungal mold has no place within human habitations and has no proper place in home or workplace especially if it poses a health risk. Scientifically, all fungi have only one role in the grand scheme of things as a catabolic molecular
processor and that is to digest and break down organic matter and
complex molecular formations into their simplest forms for
recycling. In doing so the fungi produce some interesting
chemistry and problems in the process."
So what are the problems associated
with molds? "Generally two things
are the problem, the target of the catabolic process and the
resulting byproducts of that process. First, it is OK for
mold to grow on cheese such as Brie, Camembert or Roquefort,
but when you have it growing
on and digesting your clothing, shoes, furniture or your house
then you have a problem. Second are the byproducts formed
such as the allergenic, neurotoxic, cytotoxic, genotoxic and
pathogenic secondary metabolites and extrolites that are produced.
Although less often there are the many possible fungal mold
related infections, diseases and immune responses when they
invade human or animal tissue."
are the effects of these mold toxins? "The
range of effects of toxins from mold are interesting. The
penicillin vaccine is a toxin produced by
Penicillium notatum, by some of the Aspergilli and other fungal
molds that has saved countless lives - that toxin targets
nasty bacteria. Some toxins
cause unexplained fatigue, neurological distress and
responses including but rarely hallucinations. Cytotoxic,
pathogenic and genotoxic toxins are at the focal point for
research in human health and their effect on humans is much
too often unrecognized or misunderstood by many
Should we be afraid of mold?
"Clearly the medical literature documents mold as an
etiological agent (cause,
Ed.) for many human health conditions. A recent
publication (Fungalbionics) by the American A.V. Costantini,
MD from the UN's World Health Organization Center for the
Study of Mycotoxins in Food in a collaborative work with an
international team in a collection involving hundreds of studies
document the deuteromycota, the fungal mold and their toxins
involved as the cause of many diseases. Medical mycologists
will not culture some of these fungi in the lab because they
pose such a high risk and danger for infection and death.
But for a human of average health living in a dry mold free
environment the risk is limited and they need not be concerned.
How common are mold diseases? "We
encounter infected humans and their animals from time to time
that have fungal disease. A disease caused by fungi
is called a mycosis. Often a fungal exposure or infection results in a mycosis,
abscess, necrosis or a fibroid immune response to the presence
of fungi is sometimes called a tumor or cancer. Two of my recent
studies involved a 26 year old female with a large mold growth
in her left lung that required surgical removal and a 65 year
old male with a brain "cancer" that was later diagnosed
as being 2 different fungal mold growths. She fully recovered.
His condition after excision is currently considered hopeful.
In our investigation we found their homes were fully contaminated
with the genus and species involved in their disease in spite
of the previous 2 "mold inspections" stating there
was "no mold". In just the last few weeks we took on a new case
involving a 40 year old female with a bleeding nose, possibly
due to fugal mold enzymatic necrosis. In our research pathology
I was able to identify both the genus and specie of fungi
known as Aspergillus terreus in the tissue samples and our toxicological research associates
with further analysis and serum assay were able to identify
the specific mycotoxins in the tissue samples. "
Who is at most
risk? "It is about dosage of
specific mycotoxins and exposure to specific fungal molds
and the human's health status. Genetically about 25% of the
population has an innate sensitivity to fungal mold and other
contributing factors. Some groups are clearly more vulnerable.
The humans most at risk are neonates, infants, elderly, diabetics
and those that have become neutropenic
(low white blood cell count)
or immunocompromised for many reasons including cancer
patients that have received chemo or radiation therapy and
those that have been on prolonged regimen of antibiotic or
transplant suppression therapy. We well know many mold toxins have the ability to damage the immune system. It is very important
to keep any open wounds clean and properly treated. Infections
from fungal mold are surprisingly common not just from airborne
mold but also from food and water. If you are told by your
physician your are allergic to penicillin then you clearly
have an increased sensitivity to the genera (families)
of fungal mold that produce that toxin. But what is
even more interesting is that the presence of some of these
fungal molds may be related to yeast infections in humans.
This is the first I have heard of yeast infection being associated with mold. " Medical mycologists and physicians understand that yeasts such as the common Candidas are just a different form of the same fungi. There are many fungal molds that can turn into a yeast and some of these yeasts turn into a mold. We see this routinely in the laboratory. It is a phenomena called dimorphism, some of these fungi will also take on additional forms and are known as pleomorphs. This has been observed for over a 100 years and we now fully understood how and why these various morphologies come into being. Be aware that the so-called "Athletes' Foot " condition is a mold/yeast infection and can be contracted if barefoot at home or in the gym if these fungi are present clinically diagnosed as onychomycosis. If you have repeated foot infection throw away your footwear as it is most likely the source and harbor for these fungi and of the reinfection. "
pregnancy as a factor. "Yes, during
pregnancy olfactory sensitivity is increased for many reason
and the are immunological and hormonal changes that occur
resulting in amplified response to environmental factors and
sensitivities especially to fungi, their toxins and especially
from mold that are not experienced by males. During pregnancy
a safe, healthy and mold toxin free environment is mandatory for proper fetal
development - this is why females are often asked if they
are pregnant so to avoid alcohol, a mold toxin, along with
certain foods and medications that may affect such development.
This sensitively does diminish over time but the risk and
environmental burden if present in the home is now on the
homecoming newborn. Do not bring a newborn into a potentially
hazardous or toxic home environment-this is not to be taken
lightly, if you, a grown up or any adult family members gets
sick in the home and feel better outdoors or away you have
a problem and a with an undeveloped immune system, a newborn
is nearly defenseless. The medical studies are clear and this information
is well documented on the web."
How can I tell
if there is a mold problem in my house? "I first want start off by saying that people often tell me every house has mold-that is totally false. I have investigated homes that are over 300 years in the US and over 500 years and older in the UK and the EU with absolutely no fungi or mold presence. I also see brand new homes that have mold built right in because the construction materials were left in the rain, mold grew on it and was used to complete the construction."
"Now to go to your question about identifying a mold presence in the home. Often
you can see mold and or smell it but sometimes it is odorless
to you or there are minimal sensory indicators. In one of
our recent studies (Co. Sussex,NJ) a home owner found they had a mold problem
because their dog
was diagnosed by a veterinarian with a mold infection and put on the antifungal Itraconazole
(Sporanox) for pets. Her physician later determined she
was also mold infected. The house was later found to contain
hundreds of square feet of mold in the walls, floor and ceiling that was concealed by the seller of the recently purchased home and not noted or suspected by the home inspector. Numerous law suits were filed against sellers, inspectors, remediation companies and real estate agents-they all had a responsibility to have this property competently inspected-the odor was obvious and you could see the mold. "
Do you also find
this problem in apartments? "A little less
so than in single family houses mainly because apartments
have no cellars or attics since these areas are common harbors
and reservoirs with the potential for mold growth. Mold can be found anywhere and especially in damp basements where it is hidden in the wall. In habitations such as apartments
you will find mold most often in kitchen and bathroom ceilings,
walls and floors especially if there have been leaking steam or water pipes. Another good place to look is about the
dish or clothes washer if you have one."
Do you ever find it in the office or workplace? "We often investigate child care centers, health care and medical offices but rarely investigate the workplace such as manufacturing or related process environments due to the high level of industry, state and federal regulations that control those environments so in theory these places are very safe. From time to time and under special circumstances we accept such investigations for medical and health research purposes often on the behalf of the state or other interests due to our investigative expertise in environmental toxicology relating to mold. Some of the most interesting investigations and findings have been conducted and revealed where people are working due to the specialized and concentrated activity in the nature of the business. This is especially true in food processing areas that are not properly maintained. A recent case involving a 175,000 square foot executive office building of a bank that housed hundreds of workers we found ductwork fully contaminated with mold associated with kitchen cafeteria operation. Upon entry at the reception area the mold odor was immediately detected but almost unnoticed by the majority of workers yet symptomatic complaints were widely reported. We found fungal mold to be present throughout the building."
highly recommended that prior to taking occupancy of any new
building that management have a full investigation of the
indoor environment with a focal point for fungi, mold and bacteria especially
if there is any history of water damage. We see many instances
where companies move into a new office that has mold or other
indoor air quality issues. I continuously advise management
that any and all new offices be fully investigated before
moving workers to a new location since poor
indoor air quality or mold presence affects performance, production
and does account for lost work days. I also recommend that
management take note and observe their employees for indicators
that there may be a problem by listening to complaints and
acting promptly with a qualified and certified health risk investigation."
What are the symptoms
of mold exposure? "Depends
on many factors. Your personal health status such as the pregnancy mentioned, the amount of mold,
duration of exposure and the species of mold you are being exposed
to is very critical. Chronic fatigue syndrome is commonly associated with toxic fungi. There is also a long list of exposure symptoms of which allergic
bronchopulmonary responses are common and immediate type one responses with watery eyes, coughing and sneezing often upon the mere entry into a room with mold present.
Long term symptoms may include, pyrexia (fever), peritonitis (stomach pain), lymphadenopathy and melioidosis (swollen lymphs or glands), headache, chills, sleep disturbance, cutaneous (skin) lesions, sinusitis, itching, and more. Other times humans
experience a delayed type two response six or more hours then have
resulting flu like symptoms that may last for weeks. Then there are other exposures that result in asymptomatic responses - you
will have to attend one of my lectures. If your physician believes you have been exposed they may order or perform immunological tests
or require serum samples to be sent to a laboratory that will tell if you have had any significant mold exposure to toxins."
are there available? "We give guidance
and consultation from time to time to medical doctors new
to practical medical mycology. There are many different tests available
that your physician can prescribe if there are indications
that the tests are called for. If your home or habitation
was investigated and there is history of water damage or a
significant mold presence you should provide a qualified investigation
report to your physician and allow the physician to determine
relevancy to your health. Your immune system typically responds
with elevated IgE and IgG
and other antibodies in both salvia and blood when exposed
to members of the genus Aspergillus
and Penicillium, both are a common allergenic
fungal mold group. Skin prick tests (SPT) and Enzyme Linked
Immuno-Sorbent Assays (ELISA) will help to determine your
mold and other sensitivities (allergens) and exposure to clinically
relevant fungi or mold. There are other tests, markers and
indicators of exposure and infection including the use of
a fungal mold PCR panel, blood serum (plasma) analysis that your physician,
allergist or immunologist will screen you for and may order
such tests and others if such indicators of exposure or illness
are present. Medical doctors must also be mindful that some tests that indicate false positives. "
How about testing
my home? Should people test their own homes. I hear it's easy?
"I always shake my head when I
hear about testing. Testing is a methodical scientific process
considering many complex factors starting with the host. Nearly
all testing on your own is pointless. The common mold kits
you buy can be taken anywhere and something will grow and
it will be a fungi or fungal mold of some kind and even the
possibility of algae, plants, yeasts and bacteria. The often
misunderstood and misused air test kits too are a problem,
just like the sample kits they are not being used correctly
or appropriately in nearly all cases reviewed. As an example
I was called in a legal matter to review a recent inspection
where the mold spore counts were in the millions for an air
sample, such a count is not normally possible. I later interviewed
the "mold inspector" that did the testing and he
disclosed that he placed the air sampler right on top of the
mold forcing into the air cell and representing it as an "air
sample" - I am an advocate for rigorous training and
qualified certification for this practice. Internet mold inspection
diploma mills or correspondence courses just don't provide
adequate training or experience for investigating when there
is a true health risk present. "
So how should one use a mold test or sampling kit? "There
are so many different ones available each used for very specific
purposes. I could talk about tests kits ad nauseam.Test kits
in the hands of a non scientist have little value other than
telling you what we all know already that mold spores and
fragments are normally present everywhere. Without fully understanding
this simple fact and what it means to an investigator or inspector
leads to more confusion and most cases unnecessary alarm,
confusion, distress and expense. Key questions have to be
formulated for every investigation before any testing is to
be considered. If you have the potential for a fungal mold
related health problem nothing less than a fully qualified
scientific study must be performed. Simply just because you
have mold growing on a "test kit" does not mean
you have a mold problem. "
need to be aware that fungal mold is often the same color
or offers little to no contrast to the background making that
mold undetectable. A recent case in Monmouth
county had such a presence of a very nasty mold with a young
occupant with a mold infection that was later identified in
the home in a massive but unseen presence. Another case involved
a newer construction of about 5 years that had no water leaks
but presented extensive growth with hundreds of square feet
of a fungal mold known as Aspergillus that was
the same color as the surface of the construction material
almost totally invisible to the untrained eye that revealed
by special lighting then sampling identified it to pathogenic.
Aspergillus. You mention these molds by
name. Why should I know what they are? "I
know, we are often told by people that do mold clean up it
does not matter and just clean it. Well in cases that is true
if you do not have a health issue or if it is a simple case
with fungal mold about the sink or tub. If there is a health
issue or concern such as a related allergy, respiratory condition
or even an infection then you must know the allergen or pathogen,
advise your physician and then making your known exposure
part of your medical history and record. Knowing that these
fungi can and do a times cause serious health injury or disease
you certainly must know which ones they are. We provide an
important clinical section in our reports that is directed
to the attending physician to complement their diagnosis of
such indicators. "
"You also want
to know whether these fungi pose a health risk so that the
workers are adequately protected and the proper procedures
are implemented in the remediation such as full containment
and control. In the case where the mold poses no problem
as in the majority cases the remediation may only cost you
a fraction of what it may cost if you have a presence of a
mold that poses high risk or possible health injury
to workers. If the mold presence is benign it may even
be something you can do on your own saving you hundreds to
tens of thousands of dollars. On the other hand if you have
a limited presence of a potentially infectious fungi your
biggest risk is spreading it throughout the property. Only
a fully qualified specialist can determine the difference
and relevancy to your experience. Obtain a health based investigation
since a general home or mold inspection is not designed for
and is not adequate for health purposes. This also true for
legal purposes. Normal mold inspections do little to nothing
for health, forensic or legal purposes. "
Tell me about the
differences in investigation for legal purposes. "I
found law interesting enough to take a degree earlier in my
career and it turned out to be essential in my current medical research practice as
it has helped me to understand the evidentiary burdens the
law places on the scientific standards relating to claims
associated with mold and health injury claims. Too many false
positive, too many false negatives. Simply, it gets far more
complicated when trying to tie health claims and legal claims.
Ultimately as both a health and legal investigator
I have the advantage of knowledge in both areas and often
provide guidance and direction to clients and their attorneys
regarding the medical and indoor environmental tests that
must be performed. It is very unfortunate when people
have a bona fide case or a real case, that is to say
a winnable case and just do not meet the legal evidentiary
standards and their cases are dismissed. I also see cases
going on for years and then review them before trial for the
client or their legal counsel, review the medical and investigative
record and there is really nothing there but the wrong medical
lab testing and a pointless "mold inspection" citing
hearsay within hearsay and without a cohesive and comprehensive interpretation.
On the other hand in other similar situations I conduct an
investigation or inspection connected with the medical findings,
write a report that is submitted to the triers of the facts
be it in court or other tribunal such as for workers compensation
or insurance and then the case ends of a petitioner or plaintiff or is settled immediately.
If you can not definitively tie in the applicable environmental
testing with the medical tests and clinical record you will
lose a lot of time, effort and expense resulting in a dismissal.
Unfortunately for litigants I see plaintiffs and defendants
that lose cases that could have been easily won. Attorneys
and clients routinely consult me reviewing the evidence for
trial or the record for appeal. Failing to make the record at trial is nearly always fatal on appeal without a de novo hearing. "
Lets go back to mold.
Will a filter, ion or ozone machine in my home help if I think
I have odors or mold? "When
it comes to odors, indoor air quality issues or relating
to mold presence there are no simple answers to what
will provide you a benefit in any environment. These may benefit
you or not. Indoor environments can become very complex. Some
people use ozone generators, in some cases these generators
will actually make your home more toxic and dangerous and
damage your health and furnishings if not used properly. Be
careful and selective before introducing any new system especially
ozone. Obtain a expert study, opinion and recommendation before
installing such a system. Do not turn your indoor environment
and the air your breathe into a uncontrolled laboratory experiment."
So what do I do if I have odors or come
home from work and get sick all the time? "You
made the first critical observation and that is the connection
with the place that is giving you the problem. We see this
all the time. Once you have firmly concluded it is your home
that is giving you the problem then its time for a full indoor
environmental assessment. That is where the science comes
in. Unfortunately there are no simple ways of testing and
it does require a high level of expertise, instrumentation
and applicable science. Fortunately in all of my cases the
causative agents are identified within hours."
Are there any
new developments in medical mycology? "News
moves prudently in the sciences and even more so in life sciences
pertaining to human health. In the field of genomics, molecular biologists made a key
finding based upon the DNA of a bacteria. One of the causes
of pneumonia identified as Pneumocystis carinii, a parasitic
protozoan bacteria, has been reclassified and identified as
a fungi due to genomics was renamed last year (1999) as Pneumocystis
jiroveci. For medical mycologists this was an interesting
discovery and an important reclassification for treatment
Yes, but what
does that mean? "Good question,
it answers what medical mycology and molecular medicine is
all about. Simply fungi, plants bacteria and humans all have
a different molecular and cellular makeup. Drugs are designed
to target the difference in the cells, cell function, their
internal organs and reproduction. There has been an increase
in optimism for the health care profession because of this
research and we now have pharmaceuticals designing their drugs
to target these pathogens with more selectivity based upon
a better understanding of those targets."
What do we know about mold, cancer and
other fungal related diseases? "Relating
to neoplasia (abnormal
cell growth) , we know that mold produces many
toxins and exposure to some molds result in a cancer or unnatural
cell growth both hyperplasia and metaplasia. We know that
the common skin mole is more closely associated to fungal
M - O - L - D than to any M - O - L - E. That is why dermatologists
tell humans to watch for any changes in their M O L E. Mold
produces melanin to protect its DNA from UV radiation. The
melanin, brown spots, remain after a benign fungal mole has
died off or become dormant and other continue to grow into
what becomes a malignancy.
I have investigated
cases where initial diagnosis was cancer and later from biopsy
and culture identified as a mycosis. Unfortunately there
are not enough post mortem autopsies to determine the cause
of death other than nebulous catch all clinical definitions
as the cause such as "tumor" or "cancer".
magnification) also fails in histopathology
to adequately identify fungal pathogens."
"If you want
to read something very interesting see Leyland H. Hartwell's
Noble Prize in Medicine Lecture delivered on December
9, 2001. In his opening speech he introduces the fact that
in culture cancer cells just like fungal mold, often described
by histopathologists as undifferentiated carcinomas, are immortal
just like fungal mold
in that they continue to grow even outside the body, when
normal human cells do not. If cancer cells are not human cells,
then what are they? Fungal mold? I'll email you a copy or
provide a link " * download link
Are we making progress in diagnosis and treatment?
Progress on multiple fronts not just in research but also
in diagnosis and treatment of humans exposed and infected
by fungi. Working as a clinical researcher I have worked in cases with some America's leading scientists and medical researchers including
Dr. Ritchie Shoemaker, MD (Maryland)developer of a protocol for diagnosis of fungal exposure and
disease described in
"Mold Warriors", Dr. Dennis Hooper, MD (Texas)and his
pioneering assay methods for the detection of mycotoxin exposure and clinical research scientist for his work with mycoses, pathologist Dr. Michael Gray, MD (Arizona), allergist/immunologist Dr. Michael Rudenko, MD (UK) for his research with mold allergens and others in the EU."
"There are many new discoveries that scientists are just overwhelmed with their findings and conclusions. We are certainly living in very interesting times. In the past week a new book ("Cancer is a Fungus") was published written by the Roman Oncologist Dr. Tullio Simoncini, MD detailing what I and many researchers have known for years that fungi and mold are involved in nearly all cancers. Dr. Simoncini says that they are not just involved but are the cause of many if not nearly all conditions referred to as 'cancer'. The book clinically documents the 'cure' of many cancer patients some that were 'terminal'. The book is written for doctors and patients. His work is fully supported by the findings published in 'Fungalbionics' by the UN WHO's Director for the study of mycotoxins in food, Dr. Antonio Costantini, MD (California) now in Frieberg, Germany. In my opinion these doctors are truly heroes of medicine for our time."
A final question: What is happening in research?
As you know my current interest and studies in medical mycology is at the molecular level including the affect of fungal metabolites on metabolic pathways, mycotoxicity at many levels and related genomics directing the DNA lab of the Mycological Institute. Many interesting discoveries have been made. Much of the research is abstract and performed for research purposes, that which is of clinical interest we publish and present at scientific meetings and conferences.
A recent Japanese
study proved to be interesting suggesting that mold toxins have the ability to
signal the beta cells in the pancreas to shut themselves off
in a cellular process called apoptosis or programmed cell
death. These cells produce insulin. We may find a mycotoxin from a fungal
mold or yeast that is causing this disease present in type one diabetics. Other research has discovered that some cells become immortal due to mycotoxins and resulting in neoplasia."
"In wrapping up with global
research efforts in molecular medicine and medical mycology
well under way we are clearly getting a better picture of fungi and their role in human health."
Thank you for your time. "Thank
you for your interest."
For an earlier
interview (2000) and more please see: What is Fungal Mold Mycology?
For a 2012 Interview see ISHAM Berlin
Questions for the professor may be directed to:
Last Updated: December 22, 2005
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